Real-time monitoring of AAV Empty:Full Capsid Separations using Near infrared High-Precision Tunable Laser Spectroscopy(HPTLS)

In this poster from ASGCT 2025, learn about accurate measurement of AAV empty, full, and partially filled capsids is critical to gene therapy manufacturing. Nirrin’s High-Precision Tunable Laser Spectroscopy (HPTLS) offers real-time, reagent-free monitoring during chromatography that distinguishes subtle spectral differences between protein and nucleic acid content. This enables faster process optimization, improved yield, and sets the stage for real-time release strategies in AAV production.